【基本情況】

張淩，博士，研究員，博士生導師，衛生毒理與病理學系共聘研究員，國家自然科學基金委優秀青年人才項目獲得者，四川省天府人才，四川省學術和技術帶頭人後備人選。擔任中國腫瘤學會納米腫瘤專委會委員。在AdvMatt，SciAdv，AdvFuncMatt，ACSNano，CurrBiol，JCR等權威學術雜志發表論文40餘篇，獲批發明專利7項。主持及參與自然科學基金、國家科技重大專項等科研項目。

研究方向：基于微材料的健康交叉學科研究，包括醫藥用微材料的設計制備，微材料與組織間相互作用，環境微材料對健康的影響，微材料引發疾病的治療等等。

招生方向：1、分子毒理與病理學；2、環境醫學科學

聯系方式：zhangling83@scu.edu.cn

【科研課題】

自然科學基金委面上項目（81872824），針對免疫複合物腎小球腎炎的siRNA靶向遞釋系統研究，負責人。

自然科學基金委優秀青年人才項目（82022070），納米材料的生物效應研究，負責人。

【教學工作】

主講本科生課程《近代分析與測試》、《當代高分子前沿》及研究生課程《生物醫學數學》。

【近年學術成果】

(1) Lin LI; Shili SUN; Lingli TAN; Yuanfang WANG; Luyao WANG; Zhirong ZHANG; Ling ZHANG*; Polystyrene Nanoparticles Reduced ROS and Inhibited Ferroptosis by Triggering Lysosome Stress and TFEB Nucleus Translocation in a Size-Dependent Manner,Nano Letters, 2019, 19(11): 7781-7792

(2) Mengke QU; Qing LIN; Luyi HUANG; Yao FU; Luyao WANG; Shanshan HE; Yu FU; Shengyong YANG; Zhirong ZHANG; Ling ZHANG*; Xun SUN*; Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease,Journal of Controlled Release, 2018, 287: 156-166

(3) Yu FU; Wei LIU; Luyao WANG; Biyue ZHU; Mengke QU; Liuqing YANG; Xun SUN; Tao GONG; Zhirong ZHANG; Qing LIN*;Ling ZHANG*; Erythrocyte-membrane-camouflaged nanoplatform for intravenous glucose-responsive insulin delivery,Advanced Functional Materials, 2018, 28(41): 1802250

(4) Lan Yang, Yongshun Zhang, Yu Zhang, Yani Xu, Yuai Li, Zhiqiang Xie, Hairui Wang, Yunzhu Lin, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, andLing Zhang*; Live Macrophage-Delivered Doxorubicin-Loaded Liposomes Effectively Treat Triple-Negative Breast Cancer,ACS Nano, 2022, 16(6):9799–9809

(5) Zheng, Yaxian; Xing, Liyun; Chen, Liqiang; Zhou, Rui; Wu, Jiawei; Zhu, Xi; Li, Lian; Xiang, Yucheng; Wu, Ruinan;Zhang, Ling*; Huang, Yuan*; Tailored elasticity combined with biomimetic surface promotes nanoparticle transcytosis to overcome mucosal epithelial barrier, Biomaterials, 2020, 262: 120323

(6) Xiaoyu Hong; Xiaofang Zhong; Guangsheng Du; Yingying Hou; Yunting Zhang; Zhirong Zhang; Tao Gong;Ling Zhang*; Xun Sun*; The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency,Science advances, 2020, 19(6): 1-13

(7) Shiqi Huang, Yining Zhu,Ling Zhang*, Zhirong Zhang; Recent Advances in Delivery Systems for Genetic and Other Novel Vaccines,Advanced Materials, 2022, 2107946

(8) Yuai Li, Lan Yang, Xiaomin Xu, Min Li, Yicong Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang,Ling Zhang*; Multifunctional size-expandable nanomedicines enhance tumor accumulation and penetration for synergistic chemo-photothermal therapy,ACS Appl. Mater. Interfaces, 2021, 13(39):46361–46374

(9) Qingsi Wu, Jiading Wang, Yuanfang Wang, Ling Xiang, Yulu Tan, Jiaxing Feng, Zhirong Zhang*,Ling Zhang*; Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment,Nano Research, 2022, 15:3556–3568

(10) Yuanfang Wang, Qingsi Wu, Jiading Wang, Lin Li, Xun Sun, Zhirong Zhang,Ling Zhang*; Co-delivery of p38αMAPK and p65 siRNA by novel liposomal glomerulus-targeting nano carriers for effective immunoglobulin a nephropathy treatment,Journal of Controlled Release, 2020, 320:457-468

【獲獎情況】

2021年四川省學術和技術帶頭人後備人選

2019年四川省天府人才