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張遵真

發布時間 :2022-06-22      來源 :       浏覽量 :

基本情況

張遵真,醫學博士,澳门新葡萄新京威尼斯華西公共衛生學院勞動衛生與環境衛生學系,教授,博士研究生導師,四川省學術技術帶頭人,四川省衛生健康委環境與健康首席專家。

社會任職

四川省中華預防醫學會環境衛生分會常委;四川省預防醫學學會環境衛生分委會主任委員;中國醫院建設及裝備協會醫院水系統學組專家;四川省環境科學學會理事,四川省成都市環境學會主任委員。《澳门新葡萄新京威尼斯學報(醫學版)》、《環境衛生學雜志》、《中國食品衛生雜志》編委,《預防醫學情報雜志》副主編。

研究方向

(1)長期研究環境與健康,特别是環境污染物誘導氧化應激在緻癌機制中的作用;近年緻力于表觀遺傳學解析環境暴露與人群健康效應;

(2)精通環境健康風險評價和環境衛生标準研制的理論與實踐,在環境污染物緻癌評價理論方面深有建樹;

(3)善長環境因素“有利與有害”效應辨析,熟悉保健食品、化妝品、消毒劑等的毒性評價和植物提取物的功能性評價理論與實踐。

成果簡介

作為負責人主持過6個國家自然科學基金項目,多個四川省科技廳和成都市科技局科研項目;發表科研論文近300篇,其中60多篇發表在國際環境科學、毒理學、藥理學類主流期刊,具有較好影響力。參編過《環境衛生學》、《現代環境衛生學》、《中華醫學百科全書環境衛生學》等教科書、教輔書的章節。

聯系方式:電子郵箱,zhangzz@scu.edu.cn,手機:13689067422

【科研項目】

  1. 國家自然科學基金委員會,面上項目,82073510,N6-甲基腺苷結合蛋白YTHDF2相分離在砷誘導氧化應激中的作用和機制,2021.1-2024.12,56萬元,在研,主持

  2. 四川省科技廳,重點項目,2020YJ0230,FAS和PPARα作為非酒精性脂肪性肝病聯合治療靶點的作用及機制研究。2020-2022,40萬,在研,主持

  3. 國家自然科學基金委員會,面上項目,81773380,N6-甲基腺苷通過P53信号通路參與砷誘導細胞惡性轉化的機制研究,2018.01-2021.12,50萬元,已結題,主持

  4. 國家自然科學基金委員會,面上項目,81372945,P53蛋白二階段磷酸化修飾在砷“緻癌與治癌”雙重作用中的機制研究,2014.01-2017.12,70萬元,已結題,主持

  5. 成都市科技局,惠民項目,2015-HM01-00064-SF,成都市高校學生安全教育現狀與高校安全教育評估體系的建立,2015.12-2017.12,10萬元,已結題,主持

  6. 國家自然科學基金委員會,面上項目,Nrf2-AREs和NF-κB信号通路及其交互作用在低水平砷誘導細胞凋亡中的作用,81172632,2014.01-2017-12,70萬元,已結題,主持

  7. 國家自然科學基金委員會,面上項目,30872079,DNA聚合酶β表達水平的改變在環境污染物遺傳毒性中的作用,2009-01至2011-12,32萬元,已結題,主持

  8. 國家自然科學基金委員會,面上項目,30571535,HOGG1低表達細胞株的建立及其在DNA氧化損傷與肺癌相關性中的研究,2006-01至2008-12,27萬元,已結題,主持

【代表性學術成果】

  1. Donglei Sun, Chao Zuo, Wei Huang, Jingjing Wang, Zunzhen Zhang, Triclosan targeting of gut microbiome ameliorates hepatic steatosis in high fat diet-fed mice, The Journal of Antibiotics,2022,https://doi.org/10.1038/s41429-022-00522-w,

  2. 王婷,孫東雷,趙田禾,張遵真.中國直飲水及相關衛生标準比較分析,澳门新葡萄新京威尼斯學報(醫學版),2021,52(5):729-734。

  3. Ting Wang, Donglei Sun, Qian Zhang, Zunzhen Zhang*.China's drinking water sanitation from 2007 to 2018: A systematic review. Science of the Total Environment, 2121,757:143923.

  4. Donglei Sun, Tianhe Zhao, Keyan Long, Mei Wu, Zunzhen Zhang. Triclosan down-regulates fatty acid synthase through microRNAs in HepG2 cells, European Journal of Pharmacology,2021;907:174261...

  5. 左超,孫東雷,王靜靜,黃維,張遵真,三氯生改善非酒精性脂肪性肝病小鼠的肝髒脂肪沉積,現代預防醫學,2021.48:22,4176-4180

  6. Tianhe Zhao, Donglei Sun, Manyu Zhao,Yanhao Lai, Yuan Liu,and Zunzhen Zhang.N6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53activation. Environmental pollution,2020,259:113908,

  7. Donglei Sun, Tianhe Zhao, Ting Wang, Mei Wu and Zunzhen Zhang. Genotoxicity assessment of triclocarban by comet and micronucleus assays and Ames test. Environmental science and pollution research.2020, 27:7430-7438

  8. Xinyang Li, Donglei Sun, Tianhe Zhao, Zunzhen Zhang. Long non coding RNA ROR confers arsenic trioxide resistance to HepG2 cells by inhibiting p53 expression. European journal of pharmacology, 2020,872:172982

  9. Xinyang Li, Zuo Chao, Donglei Sun, Tianhe Zhao, Zunzhen Zhang. Arsenite increases Linc-ROR in human bronchial epithelial cells that can be inhibited by antioxidant factors. Biological trace element research,2020 ;198(1):131-141.

  10. Xinyang Li, Zuo Chao, Mei Wu, Zunzhen Zhang. Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity. metallomics, 2020, 12, 963-973.

  11. Donglei Sun, Tianhe Zhao, Qian Zhang, Mei Wu, and Zunzhen Zhang.Fat mass and obesity-associated protein regulates lipogenesis via m6A modification in fatty acid synthase mRNA. Cell Biol Int., 2020;1-11.

  12. Hongyu Chen, Tianhe Zhao, Donglei Sun, Mei Wu, Zunzhen Zhang. Changes of RNA N6-methyladenosine in the hormesis effect induced by arsenite on human keratinocyte cells. Toxicology in vitro, 2019,56:84-92.

  13. Tianhe Zhao, Xinyang Li, Donglei Sun, Zunzhen Zhang.Oxidative stress: One potential factor for arsenite-induced increase of N6-methyladenosine in human keratinocytes. Environmental Toxicology and Pharmacology, 2019,69:95-103.

  14. Donglei Sun, Tianhe Zhao, Xinyang Li & Zunzhen Zhang. Evaluation of DNA and chromosomal damage in two human HaCaT and L02 cells treated with varying triclosan concentrations. Journal of Toxicology and Environmental Health, Part A Current Issues. 2019;82(7):473-482

  15. Donglei Sun, Tianhe Zhao, Ting Wang, Mei Wu and Zunzhen ZhangGenotoxicity assessment of triclocarban by comet and micronucleus assays and Ames test.Environmental science and pollution research.2019, 12yue online,DOI/org/10.1007/sii356-019-07351-9

  16. Shiyan Gu, Donglei Sun, Huangmei Dai, Zunzhen Zhang.N6-methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells. Toxicology Letters, 2018,292:1-11.

  17. Shiyan Gu, Donglei Sun, Xinyang Li, Zunzhen Zhang. Alterations of miRNAs and their potential roles in arsenite-induced transformation of human bronchial epithelial cells. Genes (Basel) , 2017, 8(10): E254.

  18. Shiyan Gu, Yanhao Lai, Hongyu Chen, Yuan Liu, Zunzhen Zhang. miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing apoptosis in lung cancer cells. Sci Rep. 2017, 7(1): 12155.

  19. Chengzhi Chen, Xuejun Jiang, Shiyan Gu, Zunzhen Zhang. MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells. Toxicology Letters, 2017, 278: 38-47.

  20. Tianhe Zhao; Lichun Wu; Xinyang Li, Huangmei Dai and Zunzhen Zhang._Large intergenic non-coding RNA-ROR as a potential biomarker for the diagnosis and dynamic monitoring of breast cancer. Cancer Biomarkers, 2017, 20:165-173.

  21. Qingyin Luo, Jill M. Beaver, Yuan Liu and Zunzhen Zhang. Dynamics of p53: A Master Decider of Cell Fate. Genes, 2017, 2017 Feb 9;8(2), pii: E66.

  22. Hongyu Chen, Shiyan Gu, Huangmei Dai, Xinyang Li, Zunzhen Zhang, Dihydroartemisinin Sensitizes Human Lung Adenocarcinoma A549 Cells to Arsenic Trioxide via Apoptosis. Biol Trace Elem Res, 2017,179(2)203-212.

  23. Xuejun Jianga, Chengzhi Chena, Shiyan Gu, Zunzhen Zhang, Regulation of ABCG2 by nuclear factor kappa B affects the sensitivity of human lung adenocarcinoma A549 cells to arsenic trioxide. Environmental Toxicology and Pharmacology,2018,57: 141–150

  24. Chengzhi Chen, Shiyan Gu, Xuejun Jiang, Zunzhen Zhang. Nuclear translocation of nuclear factor kappa B is regulated by G protein signaling pathway in arsenite-induced apoptosis in HBE cell line. Environ Toxicol. 2016, 31(12):1819-1833.

  25. Shiyan Gu, Chengzhi Chen, Xuejun Jiang, Zunzhen Zhang. ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells. Chem Biol Interact. 2016,245,100-109.

  26. Chengzhi Chen, Shiyan Gu, Xuejun Jiang, Zunzhen Zhang,Arsenite-Induced Endoplasmic Reticulum-Dependent Apoptosis Through Disturbance of Calcium Homeostasis in HBE Cell Line,Environmental Toxicology,2017,32:197-216.

  27. Chengzhi Chen, Xuejun Jiang, Shiyan Gu, Yanhao Lai, Yuan Liu, Zunzhen Zhang. Protection of Nrf2 Against Arsenite-induced Oxidative Damage is Regulated by the Cyclic Guanosine Monophosphate-Protein Kinase G Signaling Pathway. Environmental Toxicology,Environ Toxicol. 2017, 32(8):2004-2020.

【獲獎情況】

2022年,被中國科技論文在線評為2021年中國科技論文在線評審的優秀評審專家;

2021年,獲得澳门新葡萄新京威尼斯指導本科畢業論文三等獎;

2020年,張遵真老師在澳门新葡萄新京威尼斯2019年本科教學工作中成績突出,獲得課堂教學質量優秀獎;

2016年:張遵真老師在2015年澳门新葡萄新京威尼斯課程考試改革中,居室與健康成績突出,獲得非标準答案考試命題優秀獎;

2016年:張遵真在澳门新葡萄新京威尼斯2015-2016學年學生學術型社團指導工作中成績突出,榮獲學術型社團指導教師鼓勵獎;

2013年:張遵真老師,在澳门新葡萄新京威尼斯2012年本科教學工作中成績突出,被評委文化素質公選課最受歡迎教師;

2013年:指導的畢業論文獲2008屆優秀畢業論文三等獎。


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